Symbol
Name
ID

Tal1
T cell acute lymphocytic leukemia 1
MGI:98480

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemias	Lymphoma
Disease(s) Associated with TAL1
acute lymphoblastic leukemia

Mouse Phenotypes

hematopoietic system phenotype

abnormal embryonic hematopoiesis

abnormal embryonic erythropoiesis

abnormal thymus morphology

enlarged spleen

increased spleen weight

absent common myeloid progenitor cells

abnormal erythropoiesis

extramedullary hematopoiesis

anemia

microcytic anemia

impaired hematopoiesis

abnormal bone marrow cell morphology/development

decreased bone marrow cell number

abnormal megakaryocyte morphology

abnormal erythroid progenitor cell morphology

abnormal megakaryocyte progenitor cell morphology

abnormal proerythroblast morphology

decreased hematocrit

decreased hemoglobin content

decreased mean corpuscular hemoglobin concentration

decreased mean corpuscular volume

increased red blood cell distribution width

anisocytosis

thrombocytopenia

decreased leukocyte cell number

increased hematopoietic stem cell number

abnormal splenic cell ratio

Availability

Mouse Genotype

Tal1^tm1.1Bgo/Tal1^tm1.1Bgo

Tal1^tm1Por/Tal1^tm1Por

Tal1^tm1Sho/Tal1^tm1Sho

Tal1^tm1Wehi/Tal1^tm1Wehi

Tal1^tm2Wehi/Tal1^tm2Wehi

Tal1^Hpt/Tal1⁺

Tg(Lck-Tal1)4709Led/0

Tal1^tm2Sho/Tal1^tm2Sho
Tg(Mx1-cre)1Cgn/0 (conditional)

Tal1^tm3Wehi/Tal1^tm2Wehi
Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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